Asymchem JACS Publication on Development of Electrochemical Reduction Coupling Reactions of Olefins and Ketones
Recently, Asymchem published a paper titled “Electroreductive Olefin-Ketone Coupling” in JACS (Journal of the American Chemical Society), which is one of the leading academic journals in chemistry. This breakthrough in electro-mechanical chemical synthesis was achieved by Asymchem’s Center of Excellence for Process Science in collaboration with Dr. Phil S. Baran’s group at the Scripps Research Institute and Prof. Minteer’s group at the University of Utah. This team successfully solved the challenges of low synthesis efficiency associated with this type of transformation via traditional reactions. The process is not only simple to operate, but also has great potential and values for very broad ranges of application. Asymchem has continued to cultivate the development and application of advanced green manufacturing technologies over the years, and has published several related articles in top industry journals such as Nature, Science, Chemistry-A European Journal, and JACS, and has been granted several patents. The development of the electrochemical reduction coupling process for inactive ketones and olefins will continue to promote the application of electrochemistry in API synthesis and supports the trend toward more eco-friendly solutions in the industry.
Patent Granted: “Ketoreductase Mutant and its Application”
The patent of “Ketoreductase mutant and its application” developed by Asymchem was granted (No. CN108048417B). The new ketoreductase developed by enzyme evolution technology is highly stable, especially tolerant to acetone and isopropyl alcohol. It significantly simplified system, results in cost reduction in the preparation of chiral hydroxyheterocyclic substances. It could also be used in the biosynthesis of thiopenan side chain R-3-hydroxytetrahydrofuran and R-3-hydroxytetrahydrothiophene. Chiral purity of the alcohol products are extremely high with e.e. values as high as 99.6% and 99.8%, respectively.
Patent Granted: “L-amino acid ligase Slal, its preparation method and application”
The patent of “L-amino acid ligase Slal, its preparation method and application” developed by Asymchem was granted (No. CN 111440777B). It was discovered by screening through gene mining for an efficient amino acid ligase, which has a wide substrate spectrum and can be applied to synthesize a variety of homo- and heterotypic dipeptides.
Patent Granted: “Synthetic Column for RNA and DNA Synthesis and its system”
Asymchem’s patent of “Synthetic Column for RNA and DNA Synthesis and its system” was granted (No. CN212640460U). This practical invention is suitable for the synthetic column of RNA and DNA. It features great flexibility and is easy to assemble. It could be used to prepare a wide variety of oligonucleotides, while reducing the waste from solid phase carrier CPG. It also minimizes in-homogeneity of reagents in the column resulted from fluid flow pattern which improves the overall stability of the liquid phase in the column. As a result, column efficiency, life span and overall cost efficiency could be greatly improved.
Patent Granted: “Synthesis Method of Degarelix Acetate”
Asymchem’s patent “Synthesis Method of Degarelix Acetate” was granted (No. CN110330552A). This achievement provides an efficient way of making digarelix acetate which effectively avoids many side reactions, low yield and high cost associated with solid phase synthesis.
Patent Granted: “Photochemical synthesis method of heteroaryl amine compounds”
The patent of “Photochemical synthesis method of heteroaryl amine compounds” of Asymchem was granted (No. CN111732535B). This method could achieve catalytic reduction of many different types of nitro heteroaryl compounds under light, obtaining heteroaryl amines in high yields. Typical photocatalysts are used. It does not have stringent requirement on instruments and could be easily recycled. As a result, heteroarylamines could be synthesized much more safely and cost effectively with much higher yield as there is no need for any metal catalysts or reducing agents. The entire procedure is simple and environmentally friendly.