API Solutions

Continuous Flow

Productivity Innovation from Reaction to Workup

Asymchem has successfully developed “end to end” continuous process to replace conventional batch process from reaction to workup. Through the combination of process optimization, modularization, and automation, continuous flow can improve the productivity and quality of pharmaceuticals. Our platform has improved process robustness, reduced chemical waste, and is much better at handling unstable chemicals. Our continuous flow platform has been applied to and improved productivity of multiple key intermediates and API commercial projects of pharmaceuticals — all of which comply with the GMP requirements.

Reaction Types

  • Electrochemical Reaction
  • Diazomethane Reaction
  • Dibal-H Reaction
  • High-Temperature Reaction (≥ 150ºC)
  • Low-Temperature Reaction (≤ -20ºC)
  • Curtius Rearrangement Reaction
  • Continuous Catalytic Hydrogenation Reaction
  • Continuous Reaction with High Energy Reagents
    (TMSN3, NaN3, H2O2, TBHP, etc.)
  • Continuous Ozonolysis / Ozonation Reaction
  • Continuous Nitration Reaction


  • From milligrams (mg) to 8 metric tons (mt)
  • 80% waste decrease Rh catalyst

Production Example