Technology Updates
Chemical Engineering Department’s Reaction Kinetics Process Development Business Expansion
The Chemical Engineering Department (CED) of Asymchem recently expanded its reaction kinetics process development business. CED uses automated reaction condition control equipment such as Easymax and RC1, combined with an online infrared detector, online HPLC, and other real-time detection tools to accurately obtain reaction process data. The department utilizes advanced software tools to regress reaction kinetic parameters on reaction data combined with reaction mechanism, and finds the key factors affecting reaction speed, conversion rate, and impurity level. This allows for a small number of experiments needed to obtain accurate experimental data and establish the reaction model. It uses the reaction model to simulate a large number of virtual experiments and verify the accuracy of the model, to quickly find the control range of process parameters, and to guide the process scale-up and large-scale production scientifically.
Patent Granted: “A Synthetic Method of Aromatic Acetal Compounds”
Asymchem’s patent “A synthetic method of aromatic acetal compounds” was granted (No. CN107311829B). By continuously feeding the mixed solution of reaction raw materials into the reactor for enaminization reaction, it successfully realizes the continuous enaminization reaction and the continuous production of aromatic acetal compounds. This significantly shortens the reaction time, largely improves the reaction efficiency, and reduces the production cost, which is expected to better meet the market demand for aromatic acetal.
Patent Granted: “Continuous Preparation Device and System for Grignard Reagent” granted
Asymchem’s patent “Continuous Preparation Device and System for Grignard Reagent” was granted (No. CN212068771U). The utility model provides a Grignard reagent continuous preparation device and system, includes column reactor and oscillator, which can realize the continuous and efficient mixing and reaction of halogenated hydrocarbon raw materials and magnesium metal. Advantages include shortening the reaction time and obtaining a high concentration of Grignard reagent. The application of this device avoids the problems with excessive internal pressure and unstable reaction conditions with the traditional reaction system. It also increases safety and improves the quality of Grignard reagent products.
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