Empowering Every Step of the Process
In December 2022, Asymchem’s Boston site was established to provide direct service to biotech clients with a focus on providing a full range of operations and services for the company’s global partners. The site’s focus on small molecules, oligonucleotides, and peptides is only a small piece of their entire work scope.
The site is fully equipped and capable of carrying projects through early-stage phase development and beyond, including API process development, preliminary pre-formulation, solid characterization, and research and development efforts for both drug substances and drug products. The various labs led by Asymchem’s dedicated scientists are a focal point in enhancing clients’ CMC experience to make it more seamless and diversified.
As an extension of Asymchem’s China-based manufacturing, the Boston site is a necessary addition that assists in scaling projects in a more efficient timeframe without compromising the quality. As a one-stop shop for CDMO services, Boston’s site rounds out Asymchem’s internal ecosystem to support not only rising biotech companies but also more established ones that seek a fully integrated CMC experience.
Service Offerings
- Discovery Support
- Fast access of building blocks and scaffolder
- Fast purification and chiral separation
- Experience with structure complexity
- Library synthesis
- Discovery Process Chemistry
- Chemical Process R&D
- Synthetic route scouting
- Process R&D
- Scale up (up to 100g now, kilo scale in Q3)
- Fit for purpose Safety Assessment
- Preliminary DoE study
- Solid Form Characterization
- Crystal, salt and cocrystal screening
- Fit for purpose solid form selection
- Preliminary physicochemical and pharmaceutical profiling
- Analytical
- Fit for purpose analytical method development
- Preliminary stability study
- Solid characterization
Equipment
- Chemical Process R&D
- ISCO
- Prep. HPLC
- Benchtop reactors up to 10L
- Vacuum oven
- Kilo-Lab with reactors up to 100L (in Q3)
- Solid Form Characterization
- PLM
- DSC/TGA
- DVS
- Crystal 16
- XRPD (TBD)
- Analytical
- HPLC/UPLC with PDA and CAD
- LC-MS
- Karl Fischer
- GC
- NMR (TBD)